Rocket and Groot have been best friends since they met each other on Halfworld and began a life of crime together. While Rocket was cruel to everyone, he had a soft spot for his best friend and fellow partner. However, Rocket sometimes called Groot "an idiot" (something he later regretted after Groot saved their lives on the Dark Aster.
- Main article: Rocket and Gamora
When the two of them first met, Gamora nearly killed Rocket for kidnapping Peter while also trying to steal the Orb back. Rocket knew her as Gamora, the daughter of a genocidal maniac, and stated that everyone knows who everyone is. Both of them were forced to work together when they were tasked to give the Power stone away to Taneleer Tivan, the "Collector". Over time, Rocket saw Gamora (and Peter) as the first real friends he and Groot had. When Gamora was launched out of her pod and into space, Rocket painfully told Peter they had no choice but to leave her floating out in space, knowing that her mods should keep her alive a bit longer. He immediately blamed Drax for getting Quill and Gamora kidnapped by the Ravagers in the first place but later worked together to save their friends from Yondu Udonta.
The two seem to have gotten closer in Guardians of the Galaxy Vol. 2 and have a brother and sister relationship. When Rocket mercilessly says, "That's what you get when Quill flies," Gamora immediately threw something at him rather than Peter, saying they had to make out of this alive. Gamora did berate the two men for fighting rather than cooperating and stated that nearly one of them could have got them killed. However, Gamora did get mad when Nebula kept calling Rocket a fox.